Formulation Guide
- All 82
- Tablet 41
- Lozenge 5
- Effervescent Tablet 12
- Orally Disintegrating Tablets (ODT) 8
- Chewable Tablet 16
- CBD 32
- Flavored 11
- High Dose 5
- Low Dose 1
- Vitamin 29
- Beta-carotene 6
- Vitamin C 11
INGREDIENTS | mg/Tablet |
Ascorbic Acid | 1000 |
Tartaric Acid | 200 |
Sorbitol DC | 200 |
Sodium Bicarbonate | 172 |
Direct Compression
INGREDIENTS | mg/Tablet |
CBD Isolate | 100 |
Ascorbic acid | 250 |
Lactose DC | 100 |
Crospovidone | 20 |
Macrogol 6000 powder | 3 |
Pass all components through a 0.8-mm sieve, mix, and press with medium-compression force.
INGREDIENTS | mg/Tablet |
CBD Isolate | 100 |
Dextrose | 500 |
PVP 90 | 4 |
Water | 0 |
PEG-6000 (powder) | 16 |
1. Granulate mixture of items 1 and 2 with solution of items 4 and 5 (in a fluidized bed), sieve, add item 6, and press with high-compression force.
2. Compress into 620-mg tablets, using 12-mm biplanar punches.
INGREDIENTS | mg/Tablet |
Thiamine Hydrocholoride | 100 |
Lactose | 200 |
Polyvinylpyrrolidone K 30 | 10 |
Crospovidone | 9 |
Magnesium Stearate | 2 |
Silicon Dioxide | 1 |
INGREDIENTS | mg/Tablet |
Riboflavin | 100 |
Sorbitol DC | 250 |
Copovidone | 19 |
Silicon Dioxide | 10 |
Magnesium Stearate | 5 |
INGREDIENTS | mg/Tablet |
Ascorbic Acid | 110 |
Glucose Monohydrate | 500 |
Polyvinylpyrrolidone K 90 | 4 |
Poloyethylene Glycol 6000 powder | 6 |
INGREDIENTS | mg/Tablet |
Ascorbic Acid | 105 |
Microcrystalline Cellulose | 70 |
Sucrose, Ground | 32 |
Sucrose, crystalline | 20 |
Cyclamate, sodium salt | 6 |
Polyethylene Glycol 6000 | 5 |
Orange Flavor | 2 |
Strawberry Flavor | 1 |
Silicon Dioxide | 1 |
Saccharin | 0 |
INGREDIENTS | mg/Tablet |
Beta-carotene | 100 |
Ascorbic acid (crystalline) | 250 |
Sodium ascorbate | 280 |
Vitamin E acetate (dry powder, SD 50) | 500 |
Sorbitol DC | 600 |
Lactose DC | 500 |
Fructose DC | 350 |
PEG-6000 (powder) | 50 |
1. Mix all components, pass through a sieve, and press with high-compression force.
2. The 20-mm biplanar tablet has an average weight of 2.6 g.
INGREDIENTS | mg/Tablet |
CBD Isolate | 10 |
Sodium bicarbonate | 198 |
Citric acid | 100 |
1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.
2. Mix and compress at low forces.
INGREDIENTS | mg/Tablet |
CBD Isolate | 10 |
Tartaric acid (fine crystals) | 36 |
Sodium bicarbonatea | 44 |
Saccharin sodium | 20 |
Sodium chloride (milled) | 2 |
Lime flavor | 1 |
Sucrose DC | 170 |
Mix items 1-8 in a V-blender and mix for 15 minutes. Compress at low forces.
INGREDIENTS | mg/Tablet |
CBD Isolate | 10 |
Pharmaburst | 181 |
Acesulfame K | 3 |
Magnesium stearate | 2 |
Talc (fine powder) | 2 |
Dry mint flavor | 3 |
1. Sift and mix items 1, 2, 3, and 6.
2. Lubricate with magnesium stearate and fine talc powder.
3. Compress into 200-mg tablets, using 6-mm punches.
INGREDIENTS | mg/Tablet |
Loratadine | 10 |
Microcrystalline Cellulose | 44 |
AEROSIL® 200 hydrophilic fumed silica | 3 |
Magnesium Stearate | 3 |
PVP K-30 | 3 |
Purified Talc | 5 |
Mannitol | 50 |
Aspartame | 0 |
Crospovidone | 30 |
Starch | 51 |
1. Mix starch and loratadine to form a uniform mixture
2. Mix remaining excipients (mannitol, aspartame, microcrystalline cellulose, colloidal silicon dioxide, purified talc, magnesium stearate, PVPK-30, sodium starch glycolate) step wise to the uniform mixture of powder.
INGREDIENTS | mg/Tablet |
CBD Isolate | 112 |
Sorbitol DC | 200 |
Anhydrous citric acid | 1000 |
Sodium bicarbonate | 587 |
PEG-6000 (powder) | 65 |
Lemon flavor | 10 |
Cyclamate sodium | 25 |
Saccharin sodium | 1 |
1. Dry the sodium bicarbonate for 1 hour at 100.C, mix with the other components, pass all through a 0.8-mm sieve,
INGREDIENTS | mg/Tablet |
CBD Isolate | 12 |
Magnesium Trisilicate | 25 |
Lactose Mono DC Grade | 23 |
Aerosil R® 200 | 1 |
Magnesium Stearate | 1 |
Cyclamate sodium | 1 |
Menthol | 2 |
Mix all components, pass through an 0.8-mm sieve, and press with a compression force of 20 kN.
INGREDIENTS | mg/Tablet |
CBD Isolate | 13 |
Citric acid anhydrous | 650 |
Sodium bicarbonate granular | 367 |
Sodium carbonate anhydrous | 40 |
Flavor | 25 |
Color | 5 |
Sodium benzoate | 8 |
Water, purified | 2 |
1. Premix the CBD granule with sodium bicarbonate and Sodium Benzoate. Mix the color with sodium carbonate. Place citric acid in a bowl of a suitable blender.
2. Slowly add 2 mg of water to the citric acid and mix thoroughly to form a moist blend. Add to the blend, in sequence, while mixing, the sodium bicarbonate mix and the sodium carbonate color mix. Mix until uniformly dis-tributed.
3. Compress tablets using suitably sized tooling. Cure the tablets, cool, and package in aluminum foil.
INGREDIENTS | mg/Tablet |
CBD Isolate | 13 |
Maize Starch | 11 |
Mannitol, DC | 105 |
Magnesium Stearate | 1 |
A mixture containing CBDC-75, mannitol, maize starch, and microcrystalline cellulose is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 130 mg in the mas
INGREDIENTS | mg/Tablet |
CBD Isolate | 13 |
Microcrystalline Cellulose | 160 |
Magnesium Stearate | 2 |
Croscarmellose sodium type A | 4 |
1. Pre-mix CBDC-75 with one-third quantity of the microcrystalline cellulose and one-half the quantity of the anhydrous lactose in a blender for 5 minutes at 20 rpm.
2. To the premix is added the remaining two-thirds of the microcrystalline cellulose and the remaining one-half of the anhydrous lactose. Blend for 10 minutes at 20 rpm.
3. Add croscarmellose sodium to the blended powders in step 2 and mix for 5 minutes at 20 rpm.
4. Add item 4 to the mixture after passing it through a 90-mesh screen and blend for an additional 5 minutes at 20 rpm.
5. Compress into 400 mg tablets, using a suitable punch.
INGREDIENTS | mg/Tablet |
Caffeine salicylate | 150 |
Gum Base | 300 |
Sorbitol | 350 |
Lecithin | 150 |
Flavor (L –menthol) | 10 |
Mannitol | 50 |
Magnesium Stearate | 10 |
Aerosil® fumed silica | 10 |
Sweetner (Sodium Saccharin) | 10 |
1.Gum base powder and active ingredient (Caffeine salicylate) are mixed well in mortar.
2. Soy lecithin, sorbitol, mannitol, sweetner, and L-menthol are added to gum base and active mix
3.After thorough mixing, add lubricant and glidant.
INGREDIENTS | mg/Tablet |
Caffeine Powder | 150 |
Microcrystalline Cellulose | 36 |
Lactose DC | 46 |
Sucrose DC | 49 |
Croscarmellose sodium (Ac-Di-Sol SD-711) | 3 |
Silicon Dioxide | 2 |
Stearic Acid | 1 |
Magnesium Stearate | 1 |
Flavor | 1 |
1. Screen items 1, 7, and 8 separately through a 40-mesh sieve.
2. Blend items 1 to 6 and 9 in a V-shaped blender, and mix for 3 minutes.
3. Add item 8 to the blender and mix for another 5 minutes.
4. Compress, using 7 kg pressure and 3/8-in., flat, bevelededge punches to produce tablets with an average weight of 311 mg.
INGREDIENTS | mg/Tablet |
Beta-carotene | 150 |
Calcium hydrogen phosphate granulated with 5% polyvinylpyrrolidone K 30 | 175 |
Microcrystalline Cellulose | 100 |
Crospovidone | 25 |
Talc | 20 |
Silica | 5 |
Calcium Arachinate | 2 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 16 |
Microcrystalline Cellulose 101 | 50 |
Veegum F | 10 |
Sodium starch glucolate 42.00 | 8 |
Magnesium stearate | 2 |
1. Pass items 1 to 4 through a 250 mesh screen and blend for 10 minutes.
2. Add item 5, blend for 1 minute, and pass the mixture through a #11 sieve.
3. Compression at low compression force.
INGREDIENTS | mg/Tablet |
Peumus boldus (Dry Plant Extract) | 170 |
Microcrystalline Cellulose | 112 |
Lactose | 112 |
Magnesium Stearate | 6 |
1. Blend Dry plant extract and excipients, except magnesium stearate, for 12 minutes by tumbling.
2. Add corresponding amount of magnesium stearate and blended for another 4minutes.
3. Compress for 5 seconds.
INGREDIENTS | mg/Tablet |
Caffeine | 200 |
Microcrystalline Cellulose | 128 |
Dicalcium Phosphate | 42 |
Magnesium Stearate | 5 |
INGREDIENTS | mg/Tablet |
Nicotinamide | 200 |
Microcrystalline Cellulose | 100 |
Copovidone | 10 |
Magnesium Stearate | 2 |
Silicon Dioxide | 2 |
INGREDIENTS | mg/Tablet |
Ascorbic Acid, Crystalline | 200 |
Polyvinyl Acetate + Povidone K30, 8:2, Spray dried | 200 |
Magnesium Stearate | 9 |
INGREDIENTS | mg/Tablet |
Tocopheryl acetate dry powder | 400 |
Lactose DC LCE | 190 |
Silicon Dioxide | 10 |
Tocopheryl acetate dry powder 50%, spray-dried with gelatin
INGREDIENTS | mg/Tablet |
Beta-carotene (dry powder, 10%) | 20 |
Microcrystalline Cellulose | 250 |
Kollidon R CL | 20 |
Silicon dioxide | 2 |
1. Mix all components, and press with a low-compression force.
2. Compress into 518-mg tablets, using 12-mm biplanar punches.
INGREDIENTS | mg/Tablet |
CBD Isolate | 20 |
Sorbitol DC | 10 |
Tartaric acid powder | 14 |
Sodium carbonate | 19 |
PVP K25 | 2 |
PEG 6000 powder | 1 |
1. Mix all components and pass through a 0.5-mm sieve.
2. Press to tablets at 66 mg.
INGREDIENTS | mg/Tablet |
CBD Isolate | 20 |
Lactose DC | 133 |
Microcrystalline cellulose 102 | 40 |
Povidone | 24 |
Fruit Punch Flavor | 2 |
Magnesium stearate | 2 |
1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.
2. Add Magnesium stearate and mix an additional 1 minute and compress.
INGREDIENTS | mg/Tablet |
CBD Isolate | 20 |
Starch 1500 | 375 |
Microcrystalline Cellulose 102 | 328 |
Stearic Acid | 15 |
Fumed Silica | 6 |
Magnesium Stearate | 2 |
1. Blend half of the Starch 1500 with the fumed silica and CBD Granulate for 5 minutes.
2. Pass this mixture through a 40-mesh screen and return to blender.
3. Add the remaining starch 1500 to the material in step 1 and blend for 5 additional minutes.
4. Add the microcrystalline cellulose (MCC 102) and stearic acid to the material from step 2 and blend for an additional 10 minutes.
5. Add the magnesium stearate to the material from step 3 and blend for an additional 5 minutes.
INGREDIENTS | mg/Tablet |
Curcumin | 20 |
Xanthan Gum | 10 |
Sodium Starch Glycolate | 12 |
Dicalcium Phosphate | 24 |
Microcrystalline Cellulose | 84 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 22 |
Sorbitol DC | 150 |
Kollidon R® VA 64 | 5 |
Menthol (crystalline) | 5 |
Eucalyptol (crystalline) | 5 |
Aspartame, potassium | 1 |
Saccharin sodium | 0 |
Aerosil R® 200 | 2 |
Magnesium stearate | 1 |
1. Mix all components, pass through an 0.8-mm sieve.
2. Compress into lozenge, using 8-mm biplanar punches.
INGREDIENTS | mg/Tablet |
CBD Isolate | 24 |
Sodium bicarbonate | 27 |
Citric acid anhydrous | 27 |
Microcrystalline cellulose | 10 |
Xylitol | 10 |
Sucrose stearate | 2 |
1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.
2. Mix and compress at low forces.
INGREDIENTS | mg/Tablet |
Amoxicillin Trihydrate | 250 |
Health in Gum® PWD-01 | 800 |
Menthol | 10 |
Aspartame | 5 |
AEROSIL® fumed silica | 7 |
Talc | 10 |
Titanium Dioxide | 5 |
Microcrystalline Cellulose | 13 |
1. Mix Amoxicillin Trihydrate, Health in Gum® PWD-01, and Menthol in porcelain mortar.
2.Pass through 100# sieve
3.Mix blend with AEROSIL® fumed silica, Talc, and Aspartame for 5 minutes.
4.Keep in freeze for 30 minutes.
INGREDIENTS | mg/Tablet |
Calcium Pantothenate | 275 |
Calcium hydrogen phosphate | 150 |
Microcrystalline Cellulose | 50 |
Crospovidone | 20 |
Searic Acid | 3 |
Magnesium Stearate | 3 |
INGREDIENTS | mg/Tablet |
Activated charcoal | 250 |
Bolus alba (Merck) | 150 |
Kollidon 25 | 28 |
Acacia gum | 38 |
Water + isopropanol (10 + 3) | 575 |
Cremophor EL | 15 |
Isopropanol | 300 |
1. Granulate mixture of items 1 to 4 with item 5, and pass through a 1-mm sieve.
2. Dry until a relative powder humidity of 90% is reached.
3. Add solution of items 6 and 7, and pass again through a 0.8-mm sieve.
4. Dry the granules, and press into 481-mg tablets using lowcompression force and 12-mm planar punches
5. Dry the obtained tablets.
INGREDIENTS | mg/Tablet |
Rhodiola rosea L. extract (1.0% salidroside and 3.0% rosavin) | 250 |
Microcrystalline Cellulose | 500 |
Crospovidone |
INGREDIENTS | mg/Tablet |
Sodium ascorbate granular | 210 |
Ascorbic acid, powder | 70 |
Lactose DC | 195 |
Searic Acid | 14 |
Orange Flavor | 5 |
Silicon Dioxide | 3 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 28 |
Lactose DC | 225 |
Crospovidone | 10 |
Magnesium Stearate | 10 |
Mix all components, pass through a 0.5-mm sieve, and press with low compression force.
INGREDIENTS | mg/Tablet |
Ginger Dry Extract | 300 |
Polyvinylpyrrolidone | 17 |
Magnesium Aluminometasilicate | 5 |
Isomalt | 172 |
Calcium Stearate | 5 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 30 |
Lactose DC | 100 |
Magnesium Stearate | 2 |
1. Discharge all the ingredients through a 0.5-mm sieve, and mix for 10 minutes.
2. Press into 132-mg CBD tablets using medium-compression force and 8-mm biplanar punches.
INGREDIENTS | mg/Tablet |
CBD Isolate | 30 |
Sorbitol DC | 150 |
Microcrystalline Cellulose | 140 |
Crospovidone | 30 |
PEG-6000 (powder) | 40 |
Orange Flavor | 1 |
1. Pass all components through an 0.8-mm sieve, mix, and press with low-compression force.
2. Compress using 12-mm biplanar punches.
3. Crospovidone may be omitted and the tablet weight adjusted.
INGREDIENTS | mg/Tablet |
Curcumin | 30 |
PVP (Polyvinylpyrrolidone) | 20 |
Xanthan Gum | 20 |
Microcrystalline Cellulose | 132 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 31 |
Sodium bicarbonate/tartaric acid (powder) | 45 |
PVP K30 | 60 |
Sucrose (crystalline) | 40 |
Crospovidone | 20 |
PEG-6000 (powder) | 6 |
Mix all ingredients for 15 minutes and compress al high forces.
INGREDIENTS | mg/Tablet |
Ascorbic Acid | 375 |
Sodium Ascorbate | 142 |
Viamin E | 40 |
Lactose DC LCE | 840 |
Polyethylene Glycol Powder | 40 |
Orange Flavor | 25 |
Mango Flavor | 25 |
Aspartame | 20 |
Direct Compression
INGREDIENTS | mg/Tablet |
CBD Isolate | 40 |
Lactose anhydrous | 312 |
Microcrystalline cellulose | 240 |
Sodium carboxymethylcellulose | 6 |
Magnesium stearate | 3 |
CBDC-75 is first blended with one-third of microcrystalline cellulose 102 and with one-half of anhydrous lactose. The premixture obtained is then blended with both remaining excipients and it is mixed again. Sodium salt of carmellose is added under mixing to be followed with magnesium stearate to finish the mixture blending. When homogenized by forth mixing the mixture is subjected to the compression.
INGREDIENTS | mg/Tablet |
Ascorbic Acid | 40 |
Starch 1500 | 58 |
Stearic Acid | 2 |
Silicon dioxide | 1 |
INGREDIENTS | mg/Tablet |
Powdered Herb | 250 |
Lactose DC | 10 |
Microcrystalline Cellulose | 30 |
Magnesium Stearate | 5 |
Talc | 5 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 45 |
Gelatin Powder | 175 |
Croscarmellose sodium | 3 |
Talc | 3 |
Magnesium Stearate | 3 |
1. Add CBDC-75, gelatin, and croscarmellose sodium, one item at a time, in a suitable blender, and mix for 15 minutes.
2. Add talc and magnesium stearate, and mix for an additional 5 minutes.
3. Compress into 230-mg tablets, using 6-mm punches.
INGREDIENTS | mg/Tablet |
Ondansetron Hydrochloride | 4 |
Sodium Starch Glycolate | 2 |
Croscarmellose Sodium | 2 |
Mannitol | 9 |
Microcrystalline Cellulose | 58 |
Sodium Saccharine | 0 |
Mint Flavor | 2 |
AEROSIL® Fumed Silica | 1 |
Magnesium Stearate | 0 |
Pass Mannitol, Sodium Starch Glycolate, and Croscarmellose Sodium were through a 100 mesh screen prior to mixing.
Mix Ondansetron Hydrochloride to sieved blend of powder.
Add and mix mint Flavor, Aerosil®, and Magnesium Stearate
INGREDIENTS | mg/Tablet |
Whole milk powder | 275 |
Microcrystalline Cellulose | 75 |
Povidone | 20 |
Sucrose | 75 |
Talc | 50 |
Magnesium Stearate | 5 |
1. Mix all ingredients except magnesium stearate thoroughly using double cone blender for 15 minutes. Set the speed of the blender to 35 revolutions per minute.
2. Compress mixed excipients into a 10mm slug or tablets using a rotary tableting press.
3. Crush slug into small granules using an oscillating granulator. The granules produced will be used for final compression.
4. Add magnesium stearate to the formulation granules and mix again using double cone blender at 35 revolutions per minute for 15 minutes.
INGREDIENTS | mg/Tablet |
Sodium Bicarbonate | 696 |
Tartaric Acid | 594 |
Ascorbic Acid | 450 |
Sorbitol DC | 212 |
Granulated Sdium Ascorbate | 106 |
Sodium Benzoate | 83 |
PEG 6000 | 63 |
Orange Flavor | 41 |
Sodium Saccharinate, ground | 8 |
In a mixer, pour and mix for 5 minutes in 6 steps:
1. Tartaric acid and sodium bicarbonate
2. Ascorbic acid and sodium ascorbate
3. Sorbitol DC, flavor and sodium saccharinate
4. A third of PEG 6000 and sodium benzoate
5. A third of PEG 6000 and sodium benzoate
6. A third of PEG 6000 and sodium benzoate. The powder is ready to be compressed.
INGREDIENTS | mg/Tablet |
Ascorbic Acid | 530 |
Sorbitol DC | 50 |
Polyethlene Glycol 6000 | 37 |
Cyclamate | 10 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 50 |
Sorbitol DC | 85 |
Lactose (120 Mesh) | 10 |
FD&C Yellow Dye No. 5 lake | 3 |
Microcrystalline Cellulose 101 | 83 |
Silica Gel | 12 |
Lemon Flavor | 8 |
Starwberry Flavor | 1 |
Sodium cyclamate | 8 |
Magnesium Stearate | 33 |
1. Pass CBDC-75 granulate, sodium ascorbate, sorbitol, lactose, FD&C Yellow Dye, microcrystalline cellulose, silica gel, flavors, and sodium cyclamate through a 420-mircrogram screen.
2. Using a comminuting mill, pass the coarse granules through a 420-microgm screen (knives forward, medium speed).
3. Transfer milled materials to a suitable blender, and blend for 5 minutes.
4. Screen the magnesium stearate by hand through an 840-microgm screen, and transfer to blender.
5. Mix for 1 minute.
6. Compress using 18-mm standard concave punches.
INGREDIENTS | mg/Tablet |
CBD Isolate | 50 |
Dextrose | 400 |
PVP 90 | 4 |
PEG-6000 (powder) | 6 |
Pass all ingredients through a 0.8-mm sieve and press with high-compression force.
INGREDIENTS | mg/Tablet |
CBD Isolate | 50 |
Lactose | 346 |
Hydroxypropylmethylcellulose 2208 | 66 |
Magnesium stearate | 3 |
Colloidal anhydrous silica | 6 |
Talc | 29 |
1. Mix all ingredients except 4 for 10 minutes.
2. Add Magnesium Stearate and mix for 1 minute.
3. Compress using low compression forces.
INGREDIENTS | mg/Tablet |
Sorbitol | 296 |
Microcrystalline Cellulose | 227 |
B-complex Premix | 50 |
Cocoa Powder | 32 |
Povidone K30 | 19 |
Chocolate Flavor | 6 |
Magnesium Stearate | 6 |
Silicon Dioxide | 6 |
Mint Flavor | 3 |
Sucralose | 1 |
INGREDIENTS | mg/Tablet |
Thiamine Hydrocholoride | 55 |
Lactose DC | 290 |
Magnesium Stearate | 5 |
Silicon Dioxide | 2 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 5 |
Sorbitol DC | 150 |
Menthol (crystalline) | 4 |
Eucalyptol (crystalline) | 4 |
Aspartame, potassium | 1 |
Saccharine sodium | 0 |
Aerosil 200 | 1 |
Magnesium stearate | 1 |
Mix all components, pass through an 0.8-mm sieve, and press with medium-compression force.
INGREDIENTS | mg/Tablet |
CBD Isolate | 5 |
Mannitol DC | 93 |
Gelatin | 1 |
Aspartame | 1 |
Colloidal silicon Dioxide | 1 |
1. Pass item 2 through 0.7-mm sieve and collect in a stainless steel container.
2. Charge half quantity of step 1 in a tumbler.
3. Pass items 1 and items 3 to 5 through 0.5-mm sieve and collect in a container.
4. Add 15% Mannitol from step 1 to step 3 and mix well.
5. Compress at medium force.
INGREDIENTS | mg/Tablet |
Zolmitriptan | 5 |
Sodium Starch Glycolate | 2 |
Polyethylene Glycol 3350 | 3 |
Chitosan | 3 |
Microcrystalline Cellulose | 6 |
FlowLac® 100, Spray-dried alpha-lactose monohydrate | 60 |
Active ingredient and all additives are homogeneously blended using geometric dilution after passing through 500 micron screen sieve.
PEG 3350 is added to the mixture.
INGREDIENTS | mg/Tablet |
Beta-carotene | 70 |
Lactose DC | 113 |
Anhydrous citric acid | 200 |
Sodium bicarbonate | 120 |
Sodium carbonate | 12 |
Sodium cyclamate | 20 |
Aspartame | 15 |
Orange flavor | 20 |
PEG-6000 (powder) | 30 |
1. Pass all components through an 0.8-mm sieve and mix. Press with medium- or high-compression force at maximum 30% relative humidity.
3. Use 12-mm biplanar punches for 602-mg tablets.
INGREDIENTS | mg/Tablet |
CBD Isolate | 8 |
Lactose Granular | 24 |
Microcrystalline cellulose 101 | 40 |
Povidone | 24 |
Sodium starch glycolate | 22 |
Magnesium stearate | 2 |
1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.
2. Add Magnesium stearate and mix an additional 1 minute and compress.
INGREDIENTS | mg/Tablet |
CBD Isolate | 30 |
Sucrose, DC | 60 |
Crospovidone XL | 55 |
Orange Flavor | 3 |
Strawberry Flavor | 3 |
Microcrystalline Cellulose 102 | 155 |
Magnesium Stearate | 1 |
Mix all items for 15 minutes, pass through a sieve, add Magnesium Stearate and mix for an additional 1 minute. Press with medium compression force.
INGREDIENTS | mg/Tablet |
Aluminum Hydroxide (dried gel) | 320 |
Magnesium Hydroxide (fine powder) | 320 |
Sucrose | 32 |
Mannitol | 288 |
Povidone | 0 |
Glycerin | 12 |
Magnesium Stearate | 19 |
Fumed Silica | 6 |
Peppermint oil | 0 |
1. Mix aluminum hydroxide, magnesium hydroxide, sucrose, and mannitol in a suitable blender.
2. Add povidone and glycerin, use this to moisten the mix of the first four ingredients.
3. Granulate by passing through a 14 mesh screen.
4. Dry at 60.00 to 65.56 °C.
5. Size through a 20-mesh screen.
6. Add and thoroughly mix magnesium stearate, fumed silica, and peppermint oil.
INGREDIENTS | mg/Tablet |
Elderberries e lyophilized extract 10% | 600 |
Lactose | 172 |
Sucrose DC | 700 |
Carbomer G 71 | 18 |
Magnesium Stearate | 10 |
INGREDIENTS | mg/Tablet |
CBD Isolate | 100 |
Starch 1500 | 26 |
Microcrystalline Cellulose | 21 |
Sodium Starch Glycolate | 6 |
1. Blend all ingredients in a twin-shell blender for 10 minutes.
2. Compress into 153 mg tablets.
INGREDIENTS | mg/Tablet |
CBD Isolate | 50 |
Lactose | 200 |
Microcrystalline Cellulose | 105 |
Magnesium Stearate | 1 |
A mixture containing CBDC-75, Lactose, and Prosolv 50 is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 355mg tablets
INGREDIENTS | mg/Tablet |
CBD Isolate | 90 |
Mannitol DC | 246 |
Micrystalline Cellulose | 30 |
Aspartame | 9 |
Dyes | 1 |
Citric Acid | 1 |
Flavor | 2 |
Magnesium Stearate | 4 |
1. The CBDC-75 Granulate is coated with a layer of a taste-masking composition with a thickness of about 3 to 10 micrograms. The coating should be substantially free of cracks, holes, and other imperfections when examined under a scanning electron microscope at 100 to 500 magnification.
2. Charge items 1 to 7 in a suitable blender and mix for 20 minutes.
3. Add item 8 to step 2 and blend for 2 minutes.
4. Compress the appropriate quantity.
INGREDIENTS | mg/Tablet |
CBD Isolate | 5 |
Lactose DC | 100 |
Magnesium Stearate | 2 |
Aerosil 200 | 1 |
1. Pass all components through an 0.8-mm sieve, mix, and press with very low-compression force (4 kN).
2. Compress into 202-mg tablets, using 8-mm biplanar punches.
3. This is a very low active ingredient formulation (5 mg), if content uniformity is a problem, prepare a premix of the active ingredient with a small part of the lactose monohydrate before mixing with the other components of the formulation.
INGREDIENTS | mg/Tablet |
Beta-carotene Dry Powder 10% CWD | 23 |
Vitamin E Acetate 50% Dry Powder | 40 |
Thiamine Mononitrate | 2 |
Riboflavin Powder | 2 |
Nicotinamide | 22 |
Calcium D-Pantothenate | 11 |
Pyridoxine Hydrochloride | 2 |
Cyanocobalomin 0.1% Dry Powder | 6 |
Ascorbic Acid, Powder | 85 |
Ludipress LCE | 477 |
Sodium Bicarbonate | 600 |
Tartaric Acid | 400 |
Polyethylene Glycol 6000 | 90 |
Orange Flavor | 60 |
Aspartame | 30 |
INGREDIENTS | mg/Tablet |
Retinyl Acetate Dry Powder 500,000 I. U./g | 10 |
Thiamine Mononitrate | 2 |
Riboflavin | 2 |
Nicotinamide | 16 |
Calcium Pantothenate | 11 |
Pyridoxine Hydrochloride | 2 |
Cyanocobalamin 0.1% Coated | 6 |
Ascorbic Acid, Powder | 85 |
Tocopheryl Acetate Dry Powder 50%, Spray-dried | 31 |
Ludipress or Avicel PH 101 | 300 |
Copovidone | 21 |
Magnesium Stearate | 3 |
Orange Flavor | 7 |
Saccharin, Sodium Salt | 5 |
INGREDIENTS | mg/Tablet |
Beta-carotene Dry Powder 10% | 50 |
Thiamine Mononitrate | 3 |
Riboflavin | 3 |
Pyridoxine Hydrochloride | 3 |
Nicotinamide | 22 |
Calcium D-pantothenate | 12 |
Ascorbic Acid for Direct Compression | 100 |
Calcium Phosphate, dibasic | 550 |
Ferrous Fumarate | 80 |
Magnesium Oxide | 160 |
Cupric Sulfate | 2 |
Manganese Sulfate | 14 |
Potassium Chloride | 50 |
Zinc Sulfate | 37 |
Microcrystalline Cellulose | 60 |
Crospovidone | 50 |
Stearic Acid | 6 |
Magnesium Stearate | 5 |
INGREDIENTS | mg/Tablet |
Sorbitol DC | 20 |
Microcrystalline Cellulose | 1 |
Gelatin | 0 |
Propylparaben | 0 |
Citric Acid | 0 |
Mint Extract | 1 |
Silicon Dioxide | 0 |
Magnesium Stearate | 0 |
Salvia officinalis essential oil |
Dry excipients are blended, and the dry mix is moistened with an appropriate amount of 4.7% (w/w) microcrystalline cellulose.
The wet mass is passed through sieve number 16.
The granules are dried in a hot air oven at 40 ± 2°C for 2 hours.
The wet granules are re-sieved through number 14 sieve.
1ml of S. officinalis essential oil is mixed with sorbitol and dried in the oven for 1 min at 40 ± 2°C.
Powder containing essential oil is added to dried granules.
The granules are lubricated with 3% (w/w) magnesium stearate.
Mint extract is added as a flavoring agent.
Propylparaben is added as a preservative and antibacterial agent.
INGREDIENTS | mg/Tablet |
Sodium Bicarbonate | 300 |
Microcrystalline Cellulose | 10 |
Lactose | 5 |
Magnesium Stearate | 3 |
INGREDIENTS | mg/Tablet |
Retinyl Acetate or Palmitate Dry Powder 325,000 I. U./g Cold-water-dispersible | 355 |
Mannitol | 350 |
Copovidone | 25 |
Magnesium Stearate | 5 |
Silica, Highly Dispersed | 3 |
INGREDIENTS | mg/Tablet |
Retinyl Acetate Dry Powder 500,000 I. U./g | 163 |
Microcrystalline Cellulose | 82 |
Talc | 5 |
INGREDIENTS | mg/Tablet |
Retinyl Acetate Dry Powder 500,000 I. U./g | 66 |
Tocopheryl Acetate Dry Powder 50%, Spray-dried with Gelatin | 65 |
Sorbitol, Crystalline | 425 |
Polyethylene glycol 6000, Powder | 15 |
Orange Flavor | 15 |
Cyclamate, Sodium Salt | 9 |
INGREDIENTS | mg/Tablet |
Thiamine Hydrochloride or Thiamine Mononitrate | 25 |
Riboflavin | 25 |
Nicotinamide | 80 |
Calcium Pantothenate | 40 |
Pyridoxine Hydrochloride | 16 |
Cyanocobalamin 0.1% gelatin-coated | 16 |
Microcrystalline Cellulose | 286 |
Polyvinylpyrrolidone K30 | 16 |
Silica, highly dispersed | 3 |
INGREDIENTS | mg/Tablet |
Nicotinamide | 200 |
Microcrystalline Cellulose | 100 |
Copovidone | 10 |
Magnesium Stearate | 2 |
Silica, Highly Dispersed | 2 |
INGREDIENTS | mg/Tablet |
Pyridoxine Hydrochloride | 250 |
Microcrystalline Cellulose | 100 |
Copovidone | 13 |
Magnesium Stearate | 5 |
INGREDIENTS | mg/Tablet |
Calcium Carbonate | 600 |
Ascorbic Acid | 1000 |
Citric Acid | 1000 |
Sodium Bicarbonate | 300 |
Rutin | 50 |
Cholecalciferol Dry Powder 100,000 I. U./g | 4 |
Polyethylene Glycol 6000, powder | 300 |
Polyvinylpyrrolidone K25 or Copovidone | 100 |
Saccharin, Sodium Salt | 3 |